Below are the three main reasons for anyone getting this error: 1) An existing instance of NHSEO is running, restarting your computer is the best way to truly check if this is the reason 2) Database file (DATABASE.db3) has been moved from the default folder (My Documents\No Hands SEO) 3) You applied the portable update to the installed version. If you are updating the installed version you should use the installer and not the portable update as that was designed to be an update for the portable version. Simply apply the correct update and it should work fine.